Imipramine, the prototypical tricyclic antidepressant (TCA), is a dibenzazepine-derivative TCA. TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause Identification · Pharmacology · Interactions.
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About half of that was for Pfizer's Lipitor, which last year had $ billion in sales in the United States alone. But recent events have invigorated a long-running controversy about value of the blockbuster drug, questioning whether it is overprescribed and inappropriately advertised. The drugs are manufactured by several. Under criticism that its ads are misleading, Pfizer said Monday it would cancel a long-running advertising campaign using the artificial heart pioneer Dr. Robert Jarvik as a spokesman for its cholesterol drug Lipitor.
The long-term effect of these drugs, singly or combined, on the risk of clinical progression is unknown. We conducted a long-term, double-blind trial (mean follow-up, years) involving men to compare the effects of placebo, doxazosin, finasteride, and combination therapy. Synopsis: Doxazosin is an alpha blocker that reduces smooth muscle tone in the prostate and bladder neck; finasteride is a 5-alpha-reductase inhibitor that reduces prostate volume.