Contraindications. Chloramphenicol is contraindicated in individuals with a history of previous hypersensitivity and/or toxic reaction to it. It must not be used in the treatment of trivial infections or where it is not indicated, as in colds, influenza, infections of the throat; or as a prophylactic agent to prevent bacterial infections. Hematologic side effects due to chloramphenicol-induced bone marrow depression are the most significant adverse reactions and have included aplastic anemia, hypoplastic anemia, thrombocytopenia, pancytopenia, and granulocytopenia. Idiosyncratic aplastic anemia occurs in approximately 1 in 20, to 1 in 40, I was wondering how untreated it takes other poeple to go into consideration withdrawal.
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