Medscape - Seizure-specific dosing for Dilantin, Phenytek (phenytoin), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Some clinicians use an oral loading dose in adults who require rapid steady-state serum levels and where IV administration is not desirable. This dosing regimen should be reserved for patients in a clinic or hospital setting where phenytoin serum levels can be closely monitored. Patients with a history of renal or liver.
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Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]. Primary: Use undiluted drug and administer by slow intravenous injection at a rate not exceeding 50 mg per minute. [Package insert: Revised June ] Loading Dose: A loading dose of parenteral Phenytoin Sodium Injection should be injected slowly. Because adverse cardiovascular reactions have occurred during and after infusions, careful cardiac monitoring is needed during and after the administration of intravenous DILANTIN. Reduction in rate of administration or discontinuation of dosing may be needed. Because of the risk of local toxicity, intravenous DILANTIN.
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