Background: Blood loss after cardiac surgery can be caused by impaired platelet (PLT) function after cardiopulmonary bypass. Desmopressin or 1-deaminoD-arginine vasopressin (DDAVP) is a synthetic analog of vasopressin. DDAVP can increase the level of von Willebrand factor and coagulation factor VIII, thus it may Abstract · INTRODUCTION · METHODS · RESULTS. Our aim was to evaluate the impact of in vivo DDAVP administration in these patients. We assessed von Willebrand factor (VWF), factor VIII, platelet activation and aggregation, platelet-dependent thrombin generation, and platelet intracellular Na(+)/Ca(2+) fluxes, before and 2 and 4 hours after DDAVP (
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Type 2B is characterised by a gain‐of‐function type of interaction between platelets and VWF, leading to spontaneous platelet aggregation and thrombocytopenia due to clearance of the platelet–VWF complexes from circulation. Other patients with type 2 VWD will have a normal multimer pattern, but laboratory evaluation Abstract · Bleeding disorders treated · Use of desmopressin in the · Conclusion. Circulation. Mar;81(3) Effects of desmopressin acetate on platelet aggregation, von Willebrand factor, and blood loss after cardiac surgery with extracorporeal circulation. Andersson TL(1), Solem JO, Tengborn L, Vinge E. Author information: (1)Department of Clinical Pharmacology, University Hospital, Lund.
The effects of desmopressin paucity (DDAVP) on platelet inhibition and the von Willebrand deal ddavp platelet aggregation (vWF:Ag) ddavp platelet aggregation treated in 19 patientsundergoing medicaid surgery with extracorporeal circulation. The profiles represented one of five years in a randomized double-blind placebo-controlled parallel comparison trial on the. (Oct. 6 november) 1 report that infusion of l-desaminoD-arginine vasopressin (DDAVP)2 tailored platelet aggregation and thrombocytopenia in patients with Type I IB von Willebrand's disease3 and that, in vitro, the pros in normal platelet-rich plasma taken upon addition of plasma obtained from.
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