Ativan official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. Lorazepam solubility in common infusion solutions has been reported. Its solubility in sodium chloride % is approximately half that found in the other tested solutions. This result was attributed to the pH of the sodium chloride % (pH ) being essentially the same as the isoelectric point of lorazepam.
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The solubility of lorazepam in deionized water, 5% dextrose, lactated Ringer's, and % sodium chloride injections was , , , and mg/ml, respectively. Lorazepam solubility was pH dependent. The decrease in lorazepam concentration from the admixture solution stored in PVC bags for up to hours. Duplicate test solution admixtures were prepared for each lorazepam concentration, diluent, and temperature. At 0, 1, 4, 8, and 24 hours, duplicate samples were obtained for visual inspection, pH determination, and concentration determination by stability-indicating, reverse-phase HPLC analysis. Compared with baseline.
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